In this webinar, Dr. Sarah Hunt provides an introduction to the health of Two-Spirit people. First, the diversity of meanings ascribed to Two-Spirit was discussed, as a term used to describe an array of Indigenous identities and expressions of gender and sexuality. Within a social determinants framework, an overview of the impacts of colonization was provided as a key component of understanding the health of Two-Spirit people. A strengths-based approach was used to present an array of practical measures health practitioners, policy makers, and researchers can use to foster Two-Spirit health. The webinar complements the NCCAH publication An Introduction to the Health of Two-Spirit People: Historical, contemporary and emergent issues.